Our Research

  • Determine the genetic mutations that drive myeloid malignancies, the clinical consequences of specific mutations, and the biological basis of malignant transformation. 
  • ​Dissect the genetics of pre-malignant states in blood cancers and examine the effects of these pre-malignant states on the development of both cancer and non-malignant diseases.
  • Explore the development of novel therapeutics that modulate ubiquitin ligase activity to induce targeted protein degradation.​
Drivers of Myeloid Malignancies
​Determine the genetic mutations that drive myeloid malignancies, the clinical consequences of specific mutations, and the biological basis of transformation.
​​Clonal Hematopoiesis of Indeterminate Potential
Understand the genetics of pre-malignant states for blood cancers and the effects of these pre-malignant states on the development of both cancer and non-malignant diseases.
​​Therapeutic Targeting of ​Protein Degradation
Explore the development of novel therapeutics that modulate ubiquitin ligase activity to induce targeted protein degradation.