Drivers of Myeloid Malignancies
Determine the genetic mutations that drive myeloid malignancies, the clinical consequences of specific mutations, and the biological basis of transformation.
Clonal Hematopoiesis of Indeterminate Potential
Understand the genetics of pre-malignant states for blood cancers and the effects of these pre-malignant states on the development of both cancer and non-malignant diseases.
Therapeutic Targeting of Protein Degradation
Explore the development of novel therapeutics that modulate ubiquitin ligase activity to induce targeted protein degradation.