Cancer Genetics and Biology
Recurrently Mutated Genes in MDS by Category
Kennedy and Ebert, Journal of Clinical Oncology 2017
Large-scale genetic sequencing and analysis have transformed our understanding of cancer. Myelodysplastic syndrome (MDS) is a hematologic malignancy characterized by abnormal blood cell differentiation and a deficiency of mature blood cells. We are interested in identifying and characterizing the somatic mutations that cause MDS, and creating a genetic profile of the disease. In patient samples, we have characterized pre-malignant states, and charted the molecular progression of genetic lesions leading toward myeloid malignancy. These are used to predict prognosis and response to therapies in MDS patients, ultimately drive better clinical decisions and targeted treatments.
The lab studies the biological basis of transformation of hematopoietic cells by somatic mutations. The lab uses human genetic studies, genomic and proteomic approaches, and functional screens in combination with classical cell and molecular biology to understand the biological basis of myeloid malignancies. The lab has developed novel models to study myeloid malignancies, including the use of CRISPR/Cas9 genome engineering to create new disease models.
Immunofluorescence of Hematopoietic Stem Cells in the Bone Marrow
Schneider, et al., Cancer Cell 2014